The Factory Supplies Danuglipron with Good Quality and Low Price CAS2230198-03-3

• Powder: Yes
• Customized: Non-Customized
• Suitable for: Adult
• State: Solid
• Purity: >98%
• C35h41fn6o7: C35h41fn6o7
• Model NO.: 2230198-03-3
• CAS: 2230198-03-3
• Danuglipron: Danuglipron
• PF-06882961: PF-06882961
• Transport Package: 25kg/Plastic Woven Bags
• Specification: 25kg/Plastic woven Bags
• Trademark: ECHEMI
• Origin: China

Product Description

2-amino-2-(hydroxymethyl)propane-1,3-diol(S)-2-((4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate;PF-06882961-82;DanugliprontromethChemicalbookamine;UNII-2HJV78O0SS;PF-06882961tromethamine;PF06882961Tris,PF06882961Tris;2-[[4-[6-[(4-cyano-2-fluoro-phenyl)methoxy]-2-pyridyl]-1-piperidyl]methyl]-3-[[(2S)-oxetan-2-yl]methyl]benzimidazole-5-carboxylicacid
Danuglipron (PF-06882961) is a potent, orally bioavailable glucagon-like peptide-1 receptor (GLP-1R) agonist that stimulates cAMP accumulation in CHO cells expressing human and monkey GLP-1R with equivalent EC50 values. It can be used to study type 2 diabetes, obesity, and non-alcoholic steatohepatitis (NASH)
HEK293 cells stably expressing hGLP-1R fused to green fluorescent protein (GFP) (400,000 cells per well) are cultured onto 6 well plates for 24 hours and stimulated with PF-06882961 for 30 minutes. An agonist concentration of 1 μM shown to induce maximal internalization is chosen for these studies. In selected wells, cells are washed three times with PBS containing 0.1 % BSA and incubated at 37 °C for an additional 2 hours to assess reversibility of the endocytosis process. Cells are then fixed with 4% paraformaldehyde for 15 minutes at room temperature followed by three washes with PBS containing 0.1% BSA.